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Senior Software Engineer, Agents

TetraScience Open · verified Oct 24, 2026
On-site San Mateo Cambridge Senior Software Engineering

At a glance

Senior Software Engineering role at TetraScience. San Mateo · $170,000–$220,000 base.

SalaryStated by TetraScience
$170,000 – $220,000
Base salary for this role, in USD per year, as published in the posting.
This role, from TetraScienceOur estimate for the market: $197,500–$220,000Median $205,000
The range includes the market median of $205,000 for senior software engineering roles in San Mateo.
Worked out from 15 postings that stated pay, median $205,000. Last updated Oct 22, 2026.
RoleSoftware Engineering
SenioritySenior
LocationSan Mateo
WorkplaceOn-site
Base pay$170,000–$220,000
PostedAug 14, 2026 · 2mo ago
Also hiring inCambridge
Role brief

techroles summary, based on the employer's posting.

What you'll do

  • Design and maintain secure distributed applications that can handle high performance and scale
  • Build C#/.NET backend services, cloud APIs and responsive TypeScript/React interfaces
  • Create independently deployable services with AWS components such as DynamoDB, RDS, SQS and Lambda
  • Write automated tests and maintain GitHub Actions pipelines across backend and frontend systems
  • Troubleshoot production systems, improve observability and contribute to service-level objectives and lower recovery times

What you bring

  • Strong C#/.NET backend development skills and TypeScript/React experience for user interfaces
  • Production experience across customer-hosted and cloud multi-tenant software, including AWS or equivalent cloud services
  • Experience with microservices, multi-level automated testing, Git and GitHub Actions
  • Strong production troubleshooting skills and a solid grasp of cloud architecture and observability practices

Who this fits

This senior engineering role suits someone comfortable building across backend, frontend and cloud systems, and communicating technical choices with varied stakeholders. The position is remote within the United States, and visa sponsorship is unavailable.

From the employer

ABOUT TETRASCIENCE

TetraScience is the Scientific Data and AI Company building Tetra OS, the operating system for scientific intelligence. We help the world’s leading life sciences firms turn fragmented scientific data into AI-native assets and scientific workflows that accelerate discovery, development, and manufacturing. TetraScience’s growing ecosystem of strategic partners includes NVIDIA, Databricks, Thermo Fisher Scientific, Snowflake, Google, and Microsoft.

In connection with your candidacy, you will be asked to carefully review “The Tetra Way,” authored by our CEO, Patrick Grady; it is impossible to overstate the importance of this document, and you should take it literally as you decide whether our mission, culture, and expectations are right for you.

The Role

We are seeking a highly skilled Senior .NET Engineer to join our dynamic team. The ideal candidate will have extensive experience in designing and developing high-performance, scalable applications using C#, the .NET Framework, and TypeScript. The role involves implementing automated testing and leveraging GitHub Actions for CI/CD pipelines. The candidate should also be proficient in production debugging and possess excellent communication skills. Knowledge and experience with AWS cloud services are also essential.


What You Will Do

  • High-Performance, Distributed, and Scalable Application Design:
    • Architect, design, and maintain distributed applications, ensuring high performance, scalability, and security.
  • Full-Stack Development:
    • Develop backend services (primarily C#/.NET and TypeScript) and cloud APIs, as well as modern, responsive front-end applications using TypeScript/React.
  • Microservices Architecture:
    • Design and implement loosely coupled, independently deployable services using AWS services such as DynamoDB, RDS, SQS, Lambda, API Gateway, and others.
  • Automated Testing:
    • Create and maintain automated unit, integration, contract, and end-to-end tests across microservices and UI layers.
  • CI/CD Pipelines:
    • Use GitHub Actions to implement and maintain CI/CD pipelines for both backend services and front-end applications.
  • Production Debugging & Optimization:
    • Diagnose and resolve production issues in distributed systems, including service-to-service communication, CPU/memory/network bottlenecks, and AWS service performance.
  • Observability & Operational Excellence:
    • Instrument services using OpenTelemetry (or equivalent) to enable earlier fault detection, clearer alerting, and stronger operational visibility. Contribute to SLO definition and MTTR reduction efforts across the platform.
  • Collaboration & Communication:
    • Work closely with product managers, tech leads, and other engineers to deliver reliable, maintainable, and scalable solutions. Communicate technical decisions clearly to both technical and non-technical stakeholders.

Requirements

What You Will Bring

Required Skills

  • Strong proficiency in backend service development using C#/.NET.
  • Strong proficiency in TypeScript and React for front-end UI.
  • Experience building and operating software in both on-premises/customer-hosted environments and cloud-native multi-tenant environments, with an understanding of how debugging, deployment, and scaling differ between the two.
  • Hands-on experience with AWS DynamoDB, RDS, SQS (or an equivalent cloud provider) in production environments.
  • Experience with microservices patterns (service discovery, API gateway, messaging/queueing, data partitioning).
  • Experience with automated testing at multiple levels.
  • Strong Git skills and hands-on experience with GitHub Actions for CI/CD.
  • Strong troubleshooting skills for distributed systems in production.
  • Solid understanding of cloud-native architecture and AWS best practices.
  • Familiarity with observability tooling and practices (OpenTelemetry, structured logging, distributed tracing, metrics-based alerting) to support proactive issue detection.

Desirable Skills

  • Familiarity with containerization (Docker) and experience defining AWS infrastructure using CloudFormation (or AWS CDK) to support predictable and repeatable environments.
  • Experience with performance tuning and designing scalable solutions.
  • Experience with, or exposure to, scientific instrument software / Chromatography Data Systems (CDS) e.g., Waters Empower, Thermo Chromeleon, Cytiva UNICORN, Agilent OpenLab, along with knowledge of instrument integration pattern and practices is a strong plus.

Soft Skills Needed:

  • Excellent verbal and written communication.
  • Strong collaboration skills in cross-functional teams.
  • Analytical mindset with high attention to detail.

Why TetraScience

  • Mission-driven: your infrastructure directly enables scientific drug development processes that save and extend lives.
  • Builder culture: everyone ships — engineers, managers, and leadership. No passengers.
  • Technically ambitious: we are rebuilding how science-grade data infrastructure works, not deploying off-the-shelf solutions.
  • AI-first: we apply AI across every layer of the platform today, not as a future roadmap item.
  • Competitive compensation, meaningful equity, and strong benefits.

Benefits

  • 100% employer-paid benefits for all eligible employees and immediate family members
  • Unlimited paid time off (PTO)
  • 401K
  • Flexible working arrangements - Remote work
  • Company paid Life Insurance, LTD/STD
  • A culture of continuous improvement where you can grow your career and get coaching

No visa sponsorship is available for this position

The salary range for this position is $170,000-$220,000 USD. The salary range posted reflects our target baseline for this role. Final compensation is determined by a thorough evaluation of factors including the candidate’s specific experience, localized market data, and internal team equity.

Opportunity

Software Engineering work from LinkedIn, X, Reddit and Upwork, in one list.

Each morning you get everything that fits, strongest first.

Software Engineering$170k+

Find me work

By the team behind techroles.

Find me work
Opportunity

Software Engineering work from LinkedIn, X, Reddit and Upwork, in one list.

Each morning you get everything that fits, strongest first.

Find me work

By the team behind techroles.